Publications

Biomarker Detection

Label-free quantitative detection of tumor-derived exosomes through surface plasmon resonance imaging.
PubMed Abstract [LINK]

Technology Development

Plain silver surface plasmon resonance for microarray application.
PubMed Abstract [LINK]

SPR imaging for high throughput, label-free interaction analysis.

DNA, RNA, antibodies, enzymes, and a range of other proteins have been arrayed and quantitatively analyzed.
PubMed Abstract [LINK]

Liver Disease Studies

Quantitative Serum Proteomics from Surface Plasmon Resonance Imaging
PubMed Abstract [LINK]

Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity.
PubMed Abstract [LINK]

SPR Applications Review

Looking towards label-free biomolecular interaction analysis in a high-throughput format: a review of new surface plasmon resonance technologies
PubMed Abstract [LINK]

SPR Technology Review

SPR microscopy and its applications to high-throughput analyses of biomolecular binding events and their kinetics
PubMed Abstract [LINK]

Heterodimer Protein Technology

Enhancement of the Antagonistic Potency of Transforming Growth Factor-Receptor Extracellular Domains by Coiled Coil-induced Homo- and Heterodimerization
PubMed Abstract [LINK]

Fusion Proteins

Transforming Growth Factor-beta (TGF-b) Binding to the Extracellular Domain of the Type II TGF-b Receptor: Receptor Capture on a Biosensor Surface Using a New Coiled-coil Capture System Demonstrates that Avidity Contributes Significantly to High Affinity Binding
PubMed Abstract [LINK]

Real-Time Monitoring of the Interactions of Two-Stranded de NoVo Designed Coiled-Coils: Effect of Chain Length on the Kinetic and Thermodynamic Constants of Binding Biochemistry
PubMed Abstract [LINK]

Use of a heterodimeric coiled-coil system for biosensor application and affinity purification
PubMed Abstract [LINK]

Protein Arrays

Self-Assembling Protein Microarrays
PubMed Abstract [LINK]

Surface Plasmon Resonance

Parallel, quantitative measurement of protein binding to a 120-element double-stranded DNA array in real time using surface plasmon resonance microscopy.
PubMed Abstract [LINK]

Microspotting streptavidin and double-stranded DNA arrays on gold for high-throughput studies of protein-DNA interactions by surface plasmon resonance microscopy.
PubMed Abstract [LINK]