Applications / Molecular Interaction Profiling

One kinetic platform.
Eight molecular classes.

Measure affinity, kinetics and selectivity across proteins, antibodies, VHHs, peptides, small molecules, DNA and RNA, glycans and aptamers with high-density, label-free SPRi.

Array-scale
Parallel molecular comparison
Real-time
Association and dissociation
Label-free
Native interaction measurement

MOLECULAR COVERAGE

01 / ANTIBODY

Compare antibody binding
beyond a single affinity value.

Parallel sensorgrams show how each antibody reaches and maintains binding. Compare affinity, association, dissociation and specificity within one experimental framework.

  • IgG and scFv formats
  • Target-panel specificity
  • Epitope-competition workflows
  • Candidate ranking
Representative concentration-resolved SPRi sensorgrams from a VHH dataset
Representative VHH sensorgrams across a concentration series

02 / VHH

Move from VHH sequence
to comparable kinetic data.

Connect sequence-diverse VHH candidates to parallel expression, purification, quality control and SPRi measurement without emphasizing a single endpoint signal.

  • Parallel cell-free protein synthesis
  • Purification and quality control
  • Concentration-resolved sensorgrams
  • Binder and non-binder separation

03 / PEPTIDE

Build peptide interaction maps
at array scale.

Compare large peptide panels against multiple reader proteins to reveal binding strength, selectivity and interaction patterns across a consistent surface.

  • Interaction discovery
  • Affinity profiling
  • Reader-panel selectivity
  • Library-level heatmaps
550+
Peptides in a representative published program
8
Reader proteins
~4,500
Interactions in one experiment
Plexera sensor chips with multiple gold and silver surface formats
Sensor substrates and application-specific chip formats

04 / GLYCAN

Resolve glycan recognition
without fluorescent labels.

Direct photocrosslinking immobilizes unmodified glycans for real-time measurement of glycan–antibody and glycan–protein interactions.

  • Direct photocrosslinking
  • Label-free recognition
  • Surface-density comparison
  • Affinity and selectivity profiles

SHARED EXPERIMENTAL FRAMEWORK

Different molecules.
One comparable workflow.

  1. 01Define the library

    Confirm molecular formats, targets, controls and comparison goals.

  2. 02Prepare the array

    Create a controlled, high-density layout on the sensor surface.

  3. 03Measure by SPRi

    Record association and dissociation across the array in real time.

  4. 04Compare the data

    Return sensorgrams, kinetic parameters, heatmaps and ranked results.

CONSISTENT DATA OUTPUT

From raw response
to molecular decisions.

Every format is connected to the same core data structure for clear comparison and downstream prioritization.

  • Concentration-resolved sensorgrams
  • KD, kon and koff
  • Replicate-level results
  • Heatmaps and molecular profiles
  • Ranked dataset and report
RELATED SERVICEProtein / Antibody Binding→ EVIDENCEPublications→